Integrative Clinical Trials: Design and Evaluation in Multi-Modal Therapy is a foundational text that explores the scientific, clinical, and methodological principles behind researching complex health interventions that combine conventional and complementary therapies. The book presents a thorough analysis of how modern clinical trials can be designed to assess multi-modal therapeutic strategies that are increasingly used in holistic and patient-centered approaches to care. With a focus on real-world applicability, it delves into the challenges and innovations required to rigorously evaluate therapies that often involve multiple components such as pharmaceuticals, herbal medicine, acupuncture, mindfulness, physical rehabilitation, and lifestyle modification. The narrative emphasizes the need for flexibility in trial design while maintaining scientific integrity, introducing readers to adaptive methodologies, pragmatic frameworks, and mixed-methods research that are better suited for assessing the effectiveness of integrative treatments. Drawing from a wide range of case studies, the book demonstrates how diverse therapeutic modalities can be scientifically studied in combination, reflecting how care is actually delivered in practice. It addresses critical topics such as patient selection, outcome measurement, statistical modeling of complex data, regulatory and ethical considerations, and the importance of culturally sensitive approaches in global research. By blending theory with practical guidance, the book equips researchers, clinicians, and students with the tools needed to design robust, inclusive, and context-aware clinical trials in the growing field of integrative medicine. This work stands as an essential guide for advancing research methodologies that align with the realities of personalized and multi-disciplinary healthcare.